[HTML][HTML] Targeting calcium regulators as therapy for heart failure: Focus on the sarcoplasmic reticulum Ca-ATPase pump
C Kho - Frontiers in Cardiovascular Medicine, 2023 - ncbi.nlm.nih.gov
… of heart failure, and gene transfer therapies aimed at restoring … In failing human hearts,
PLN levels remain stable, whereas … positive outcomes in NYHA class II-III HF patients with …
PLN levels remain stable, whereas … positive outcomes in NYHA class II-III HF patients with …
[HTML][HTML] Targeting Ca2+ handling proteins for the treatment of heart failure and arrhythmias
A Njegic, C Wilson, EJ Cartwright - Frontiers in physiology, 2020 - frontiersin.org
… + cycling, Ca 2+ leak from the sarcoplasmic reticulum and … SERCA2a) gene transfer
successfully restored the Ca 2+ … TRPC3 overexpressing hearts were also more susceptible to …
successfully restored the Ca 2+ … TRPC3 overexpressing hearts were also more susceptible to …
Mechanisms underlying pathological Ca2+ handling in diseases of the heart
SK Lahiri, Y Aguilar-Sanchez, XHT Wehrens - Pflügers Archiv-European …, 2021 - Springer
… Ca 2+ is primarily stored within the sarcoplasmic reticulum (… using small molecule inhibitors
or gene therapy approaches. … stimulation and its downstream PKA first target LTCCs [4]. …
or gene therapy approaches. … stimulation and its downstream PKA first target LTCCs [4]. …
Mitochondrial and sarcoplasmic reticulum interconnection in cardiac arrhythmia
F Salazar-Ramírez, R Ramos-Mondragón… - Frontiers in Cell and …, 2021 - frontiersin.org
… aimed at preventing cardiac arrhythmias in cardiac disease. … with the pro-oxidant hormone
angiotensin II. After 3 weeks of … used for drug delivery places this type of therapy in the …
angiotensin II. After 3 weeks of … used for drug delivery places this type of therapy in the …
Effects of Electroporation on the Function of Sarco/Endoplasmic Reticulum Ca2+-ATPase and Na+,K+-ATPase in H9c2 Cells
V Jan, M Jusović, D Miklavčič - Applied Sciences, 2024 - mdpi.com
… AF can be treated with antiarrhythmic drug therapy, direct … + release channels (RyR) in
the sarcoplasmic reticulum (SR)… of its direct target, Acetyl-CoA carboxylase (ACC) (Figure 8). …
the sarcoplasmic reticulum (SR)… of its direct target, Acetyl-CoA carboxylase (ACC) (Figure 8). …
Calcium dysregulation in heart diseases: Targeting calcium channels to achieve a correct calcium homeostasis
… common cardiac diseases, including myocardial infarction, arrhythmia, hypertrophy, heart
failure … treatments that to date, are able to target them and to revert the pathological phenotype. …
failure … treatments that to date, are able to target them and to revert the pathological phenotype. …
SERCA2a: a key protein in the Ca2+ cycle of the heart failure
L Zhihao, N Jingyu, L Lan, S Michael, G Rui, B Xiyun… - Heart failure …, 2020 - Springer
… In the heart, the sarcoplasmic reticulum (SR) is a Ca 2+ … In addition, we will also cover the
recent gene therapy of … of SERCA2a as a research target for heart failure treatment. Kho [55] …
recent gene therapy of … of SERCA2a as a research target for heart failure treatment. Kho [55] …
[PDF][PDF] Altered Sarcoplasmic Reticulum Calcium Cycling-Targets for Heart Failure Therapy
DK Zemene, M Abdelwuhab - J Clin Exp Pharmacol, 2021 - researchgate.net
… PKA and calcium/calmodulin-dependent protein kinase type II (… of a stable Ca2+ release
complex at the cardiac SR junctional … -2 gene delivery ameliorates heart failure progression in a …
complex at the cardiac SR junctional … -2 gene delivery ameliorates heart failure progression in a …
Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device–the …
AR Lyon, D Babalis, AC Morley-Smith, M Hedger… - Gene therapy, 2020 - nature.com
… the cardiac isoform of the sarcoplasmic reticulum calcium … The subject was clinically stable
with no new symptoms and … of these the target low speed was reached (HeartMate II, 6,000 …
with no new symptoms and … of these the target low speed was reached (HeartMate II, 6,000 …
… how phosphorylation and redox modifications regulate cardiac ryanodine receptor type 2 activity to produce an arrhythmogenic phenotype in advanced heart failure
A Dashwood, E Cheesman, N Beard… - ACS Pharmacology & …, 2020 - ACS Publications
… SR via sarcoplasmic reticulum Ca 2+ -ATPase (SERCA2a) and (ii) … shown SERCA2a gene
therapy and its delivery to be safe. … be targeted in the future to reduce SCD in patients with HF. …
therapy and its delivery to be safe. … be targeted in the future to reduce SCD in patients with HF. …